What Are Current Treatment Approaches – And What Therapies Are on the Horizon?Ĭurrent treatment options for uterine fibroids run the gamut from medical intervention to non-invasive and minimally invasive therapies to hysterectomy. These definitions are often used to determine appropriate interventions and/or surgical approach. However, other imaging modalities such as saline infusion sonograpy (3-D) and MRI may provide more accurate diagnosis and better delineation of fibroid size and location.įibroids are classified based on location within the uterine wall: subserosal, intramural, and submucosal. Uterine fibroids are most often diagnosed by ultrasound as part of the evaluation for associated symptoms or when an enlarged uterus is found on physical examination. Given the fact that uterine fibroids are highly prevalent in childbearing women and are associated with decreased fertility, prompt and accurate diagnosis is important. 1 How Are Uterine Fibroids Best Diagnosed? Up to 70 percent of African American women have uterine fibroids, and these generally tend to be larger, more numerous, and produce more severe symptoms. 8,9 Clinical risk factors associated with fibroids include obesity, hypertension, nulliparity (having no biological children), family history, and race. The Center, which includes physician investigators, basic scientists, and epidemiologists, is currently involved in several studies to elucidate the molecular biology of uterine fibroid growth and etiology for associated bleeding and subfertility.įactors implicated in the development of fibroids include genetic, hormonal, and growth factors, especially transforming growth factor beta (TGFb)-related cellular changes. This fibrosis is similar to that observed in the formation of keloid scars. 5,6,7 These studies indicate that fibroids grow by accumulation of collagen and components of the extracellular matrix. While the exact etiology of fibroids is still unclear, physician-scientists at the Duke Center for Uterine Fibroid Biology and Therapy have co-authored several of the most recent studies examining the underlying disease process that leads to the formation of uterine fibroids. What Causes Uterine Fibroids, and Who Is at Risk? 4 At the same time, new studies have increased our understanding of the biology of uterine fibroids and created inroads for developing more effective medical therapies.
Minimally invasive and non-invasive treatments such as MRgFUS (MRI-guided focused ultrasound) – a novel therapy recently introduced at Duke – are providing effective treatment for fibroids while offering faster recovery and fewer complications than hysterectomy.
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3įortunately, new approaches on how to manage uterine fibroids are improving the outlook. Fibroid-related morbidity has a significant economic impact on health care: the cost of health care for women with fibroids is more than double that of women without this condition, and annual costs related to the diagnosis of fibroids are over $2 billion. 1,2 Fibroids are one of the most common indications for hysterectomy in the U.S., accounting for approximately 200,000 cases per year. While typically classified as benign, uterine fibroids can cause troublesome symptoms to approximately 30 percent of affected women, including heavy vaginal bleeding, pelvic pressure, pain, obstructive urinary and bowel symptoms, as well as reproductive difficulties. The prevalence increases with age, with an estimated 70 to 80 percent of women developing fibroids by age 50. Uterine fibroids, also known as leiomyomas or myomas, are the most common gynecologic tumor in women of reproductive age, affecting approximately 30 to 40 percent of premenopausal females. ARC® IVF Success Rate & Cost Calculator.What to Expect at a Preliminary Fertility Evaluation.Probability of Success with IVF Treatments.Find a Fertility Doctor/Clinic Near You.What if we could guarantee you a chromosomally normal embryo for transfer?.
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